hrp0094p2-427 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

High throughput screening of DSD candidate genes with the help of the powerful model Drosophila melanogaster

von der Decken Isabel , Gutiérrez Daniel Rodríguez , Sotillos Sol , Castelli-Gair Hombria James , Sprecher Simon , Lauber Anna

Drosophila melanogaster as a study model has already significantly contributed to the understanding of the mechanisms of many human diseases. So far D. melanogaster has rarely been exploited as a model for human sex development. Nanda et.al already demonstrated in 2009 that the Drosophila orthologue of SOX9, Sox100B is essential for testis development in Drosophila. Similarly, we could demonstrate that the fly homolog of STARD8, cv-c</...